In vitro enzymatic process for producing glucuronides

Details In vitro enzymatic process for producing glucuronides In vitro enzymatic process for producing glucuronides

1982-08-20

1984-10-23

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

424 65, 435 79, 435123, 435127, 435136, 435137, 435195, 435200, C12P 1956, C12P 1946, C12P 1702, C12P 1500

Patent

active

044789360

ABSTRACT:
An in vitro enzymatic process for preparing O-.beta.-D-glucuronides which comprises reacting a solution of D-glucuronic acid with a solution of a compound which has a primary alcohol, and a solution of .beta.-glucuronidase for a time sufficient to form the desired glucuronide. The glucuronides can be used for the following purposes: antiperspirants, cardiotonic agents, gastric acid inhibitors, vitamin D derivatives, treatment of psoriasis, and as antitumor agents.

REFERENCES:
patent: 3240777 (1966-03-01), Sarett et al.
patent: 4153697 (1979-05-01), Hornke et al.
patent: 4292250 (1981-09-01), Deluca et al.
Ando, et al., Synthesis of Mycophenolic Acid .beta.-D-Glucuronide and Its Antitumor Activity, J. Antibiotics, 23, 408-413, (1970).
Johnson, et al., Glucuronidation of Lipophilic Substrates, Prep. Biochem. 9, 391-406, (1979).

Affiliated with

Also associated with

Rating

In vitro enzymatic process for producing glucuronides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with In vitro enzymatic process for producing glucuronides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vitro enzymatic process for producing glucuronides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1599858