In-vitro diagnostic method for determining whether a primary bre

Details In-vitro diagnostic method for determining whether a primary bre In-vitro diagnostic method for determining whether a primary bre

1997-05-30

2000-12-12

Eyler, Yvonne

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 4, 435 71, 435 721, 436501, 436503, G01N 33574

Patent

active

061597023

ABSTRACT:
A system of diagnostic test methods are provided for diagnosing whether a primary breast tumor from an individual human subject is a clinically metastatic tumor. These in-vitro diagnostic methods detect and utilize the presence or absence of a 55 kilodalton protein for the DNA or the RNA coding for an expressing this protein as a marker and indicator of tumor metastasis. The test methods thus can detect either the presence of the protein itself, or its unique DNA, or its singular RNA individually or collectively. Each method of detection provides a reliable indicator and marker by which to clinically diagnose and determine if a primary tumor within the breast of a living human subject is now or will soon likely be a metastatic tumor.

REFERENCES:
Traish, A. M. et al. Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen-receptor negative human breast cancer. Diagnos. Molec. Pathol., 6(4): 209-221, 1997.
Traish, A. M. et al. Binding of site-directed monoclonal antibodies to an epitope located in the A/B region(amino acids 140-154) of human estrogen receptor-induced conformational changes in an epitope in the DNA binding domain. Steroids, 61:549-546, 1996.
Traish, A.M. et al., FASEB Journal, 10(6): A1144, Jun. 1996.

Affiliated with

Also associated with

Rating

In-vitro diagnostic method for determining whether a primary bre does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with In-vitro diagnostic method for determining whether a primary bre, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In-vitro diagnostic method for determining whether a primary bre will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-215463