In vitro cornea equivalent model

Details In vitro cornea equivalent model In vitro cornea equivalent model

1992-11-13

1994-12-20

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

Including perfusion; composition therefor

43524023, 435240241, 623 5, A01N 102, C12N 500, A61F 214

Patent

active

053745159

ABSTRACT:
This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro.

REFERENCES:
patent: 4485096 (1984-11-01), Bell
patent: 4546500 (1985-10-01), Bell
patent: 4760020 (1988-07-01), Neufeld et al.
patent: 5131907 (1992-07-01), Williams et al.
Xie, et al., "A simplified . . . cells," In Virto Cellular & Developmental Biology, 25:20-22 (1989).
Simmons, et al., "Corneal . . . irritancy," Toxicology and Applied Pharmacology, 88:13-23 (1987).
Zieske, J. D., Bukysoglu, G., Yankauckas, M. A., "Characterization of a . . . cells," Invest. Opthalmol. Vis. Sci., 33:143-152 (1992).
Schermer, A., Galvin S., and Sun, T. T., "Differentiation-related . . . cells," J. Cell Bio., 103:49 (1986).
Muragaki, Y., et al., "Alpha-1-VIII collagen . . . tissues," Eur J. Biochem., 207(3):895-902 (1992).
Insler, M. S. and Lopez, J. G., "Transplantation of . . . endothelium," Curr. Eye Res., 5(12):967-72 (1986).
Roat, M. I. and Thoft, R. A., "Ocular surfact . . . transplantation" Int. Opthalmol. Clin., 28(2):169-174 (1988).
Parish, W. E., "Ability of . . . inflammation," Fd. Chem. Toxic. 23.215-27 (1985).
Gordon, V. C. and Kelly, C. P., "An in vitro method . . . irritation," Cosmetics & toiletries, 104:69-74 (1989).
Goldberg, A. M., "An approach to . . . methods," Fd. Chem. Toxic., 23:205-208 (1985).
Shopsis, C., et al., "A battery of . . . cytology," Fd. Chem. Toxic., 23:259-66 (1985).
Eliason, J. A. and J. P. Elliott, "Proliferation of . . . epithelium," Investigative Ophthalmol. & Visual Science, 28:1963-69 (1987).
Trinkaus-Randall, V., et al., "Influence of substratum . . . synthesis," Investig. Ophthal. & Visual Science, 29:1800-1809 (1988).
Sundar-Raj, C. V., et al., "selective growth . . . synthesis," Invest. Ophthalmol. 19:1222-30 (1980).
Insler, et al.; Current Eye Research, vol. 5, No. 12, pp. 967-972; 1986.

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