In vitro cornea equivalent model

Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or...

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4352402, 43524023, 435240241, 424 937, A01N 102, C12N 500

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active

058276416

ABSTRACT:
This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro. This invention is also directed to the use of endothelial cells in other tissue and organ equivalents to promote basement membrane development. The cornea equivalent comprises an inner endothelial cell layer, a middle stromal cell and collagen mixture wherein the stromal cells are derived from fibroblast cells and an external epithelial cell layer, wherein the epithelial cells are derived from corneal epithelial cells.

REFERENCES:
patent: 4485096 (1984-11-01), Bell
patent: 4546500 (1985-10-01), Bell
patent: 4760020 (1988-07-01), Neufeld et al.
patent: 5131907 (1992-07-01), Williams et al.
patent: 5374515 (1994-12-01), Parenteau et al.
Xie, L., et al., Developmental Biology 25:20-22 (1989).
Simmons, S.J., et al., Toxicology and Applied Pharmacology 88:13-23 (1987).
Zieske, J.D., Bukusoglu, G., and Yankauckas, M.A., Invest. Ophthalmol. & Vis. Sci. 33:143-152 (1992).
Schermer, A., et al., J. Cell Bio. 103:49-62 (1986).
Muragaki, Y., et al., Eur J. Biochem. 207(3):895-902 (1992).
Insler, M.S., et al., Curr. Eye Res. 5(12):967-972 (1986).
Roat, M.I. and Thoft, R.A., Int. Opthalmol. Clin. 28(2):169-174 (1988).
Parish, W.E., Fd. Chem. Toxic. 23:215-227 (1985).
Gordon, V.C. and Kelly, C.P., Cosmetics & Toiletries 104:69-74 (1989).
Goldberg, A.M., Fd. Chem. Toxic. 23:205-208 (1985).
Shopsis, C., et al., Fd. Chem Toxic. 23:259-66 (1985).
Eliason, J.A. and Elliott, J. P., Investigative Ophthalmol. & Visual Science 28:1963-60 (1987).
Trinkaus-Randall, V., et al., Investig. Ophthal. & Visual Science 29:1800-1809 (1988).
Sundar-Raj, C.V., et al., Investigative Ophthalmol. Vis. Sci. 19:1222-30 (1980).

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