In vitro cornea equivalent model

Details In vitro cornea equivalent model In vitro cornea equivalent model

1994-11-08

1998-10-27

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

4352402, 43524023, 435240241, 424 937, A01N 102, C12N 500

Patent

active

058276416

ABSTRACT:
This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro. This invention is also directed to the use of endothelial cells in other tissue and organ equivalents to promote basement membrane development. The cornea equivalent comprises an inner endothelial cell layer, a middle stromal cell and collagen mixture wherein the stromal cells are derived from fibroblast cells and an external epithelial cell layer, wherein the epithelial cells are derived from corneal epithelial cells.

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