Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-04-03
2007-04-03
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C514S001000
Reexamination Certificate
active
10008107
ABSTRACT:
This patent describes a novel in vitro cell-based method for biological validation and pharmacological screening of drugs, new chemical entities (NCEs) and biologics, which is predictive of in vivo testing for efficacy and adverse events in patients, as occurs in clinical trials. The same method can be used to create an in vitro cell-based assay to identify the ‘right marketed medication for the right patient’ (personalized medicine), and to identify responders
on-responders in ongoing clinical trials with NCEs. In addition this approach can be used to identify new indications for existing medicines and new indications for NCEs that were unsuccessful in their intended uses.
REFERENCES:
patent: 6242202 (2001-06-01), H.ang.kansson
patent: 6801859 (2004-10-01), Friend et al.
patent: 2003/0113831 (2003-06-01), Hakonarson
patent: 2003/0134776 (2003-07-01), Hakonarson
patent: WO 96/35948 (1996-11-01), None
Villeneuve et al., Current Topics in Medicinal Chemistry 4(13), 1453 (2004 Abstract).
Hess et al., 2001, Trends Biotechnol. 19(11): 463-468.
Liggett, 2001, Nature Medicine 7:281-283.
Busse et al., 2001, NEJM 344: 350-362.
Wilber et al., 2000, Annals of Emergency Medicine 36: 427-431.
Drysdale et al., 2000, PNAS 97:10483-10488.
Burczynski et al., 2000, Toxicological Sciences 58: 399-415.
Nielsen et al., 2000, J. Immunology 165 (4): 2287-2296.
Kang et al., 2000, J. Biol. Chem. 275:8742-8748.
Drews, 2000, Science 287: 1960-1964.
Nanki et al., 2000, J. Immunology 164 (10): 5010-5014.
Beerli et al., 2000, PNAS 97: 1495-1500.
Naldini et al., 2000, Advances in Viral Research 55: 599-609.
Ohlstein et al., 2000, Annu. Rev. Pharmacol. Toxicol. 40: 177-191.
Poste, 2000, Scrip Magazine 11-14.
Afshari et al., 1999, Cancer Research 59: 4759-4760.
Drazen et al., 1999, Nature Genetics 22: 168-170.
Aurran-Schleinitz et al., 1999, Br. J. Haematol. 106: 357-367.
Pollard et al., 1999, Br. J. Haematol. 106: 538-544.
Nuwaysir et al.; 1999, Mol. Carcinog. 24:153-159.
Galbraith, 1999, Methods in Cellular Biology 58: 315-341.
Beerli et al., 1998, PNAS 95: 14628-14633.
Bejarano et al., 1998, Blood 92: 4256-4562.
Kim et al., 1998, PNAS 95: 2812-2817.
Luxembourg et al., 1998, Nature Biotechnology 16: 281-285.
Braxton et al., 1998, Curr. Opin. Biotech. 9:643-649.
Berki et al, 1998, J. Immunological Methods 214 (1-2): 19-27.
Martinez et al., 1997, J. Clin. Invest. 100: 3184-3188.
Blaiss, 1997, JAMA 278: 1874-1879.
Riese et al., 1995, Molecular and Cellular Biology 15: 5770-5776.
Barnes, 1995, NEJM 332: 868-875.
Green et al., 1995, Am. J. Respir. Cell Mol. Biol. 13:25-33.
Hirano et al., 1994, Transplantation 57:1341-1348.
Reichert et al., 1991, Clin. Immunol. Immunopathol. 60: 190-208.
Pierce et al., 1988, Science 239: 628-631.
Motojima et al., 1983, Allergy 38:331-337.
Jenne, 1982, J. Allergy Clin. Immunol. 70:413-416.
Gillespie et al., 1974, J. Allergy Clin. Immunol. 53: 27-33.
Parker et al., 1973, J. Clin. Invest. 52: 48-59.
Boyum, 1964 Nature 204:793-794.
Agris Cheryl H.
Horlick Kenneth R.
LandOfFree
In vitro cell-based methods for biological validation and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with In vitro cell-based methods for biological validation and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vitro cell-based methods for biological validation and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3720744