In vitro and in vivo treatment of cancer cells and treatment of

Details In vitro and in vivo treatment of cancer cells and treatment of In vitro and in vivo treatment of cancer cells and treatment of

1986-03-24

1988-05-10

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 4352402, 43524021, A61K 3702, C12N 502

Patent

active

047435909

ABSTRACT:
The cancericidal activity of all the permutations of a tripeptide compound formed from dichlorodiethylaminophenylalanine, parafluorophenylalanine and methionine bonded together with peptide links was demonstrated using seven in vitro tumor cell lines. The viabilities of each of the tumor cell lines were significantly reduced by treatment for 1 to 24 hours with 1 to 50 ug of the tripeptide per ml of carrier solvent. A pulse exposure to the tripeptide demonstrated that the reductions in tumor cell was comparable to continuous exposure. Other in vitro tests were all conducted on AKR mice.
Methods of treating virus by exposing the virus to one of the noted tripeptide compounds is also contemplated.
Methods of treating tumor cells with the tripeptides dissolved in a solvent consisting of dimethylacetamide, propylene glycol and absolute ethanol are also contemplated by the present invention.
Methods of treating tumor cells resistant to other chemotherapeutic agents is contemplated by this invention.

REFERENCES:
patent: 4087520 (1978-05-01), Bran et al.
patent: 4127534 (1978-11-01), Coy et al.
patent: 4153688 (1979-05-01), Dimicoli et al.

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