Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1983-02-23
1985-04-02
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
2601125R, A61K 3702, C07C10352
Patent
active
045087105
ABSTRACT:
The cancericidal activity of all the permutations of a tripeptide compound formed from dichlorodiethylaminophenylalanine, parafluorophenylalanine and methionine bonded together with peptide links was demonstrated using seven in vitro tumor cell lines. The viabilities of each of the tumor cell lines were significantly reduced by treatment for 1 to 24 hours with 1 to 50 .mu.g of the tripeptide per ml of carrier solvent. A pulse exposure to the tripeptide demonstrated that the reductions in tumor cell was comparable to continuous exposure. Other in vitro tests were all conducted on AKR mice.
Methods of treating virus by exposing the virus to one of the noted tripeptide compounds is also contemplated.
Methods of treating tumor cells with the tripeptides dissolved in a solvent consisting of dimethylacetamide, propylene glycol and absolute ethanol are also contemplated by the present invention.
REFERENCES:
patent: 4216208 (1980-08-01), DeBarbieri
patent: 4314999 (1982-02-01), DeBarbieri
Bekesi Julius G.
DeBarbieri Augusto
Hazel Blondel
Proter S.p.A.
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