In vitro activation of cytotoxic t-cells using insect cells expr

Details In vitro activation of cytotoxic t-cells using insect cells expr In vitro activation of cytotoxic t-cells using insect cells expr

1994-03-10

1996-06-25

Adams, Donald E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352401, 4352523, 4353201, C12N 516, C12N 522, C12N 1500

Patent

active

055299210

ABSTRACT:
The present invention relates to a rational, elegant means of producing, loading and using Class I molecules to specifically activate CD8 cells in vitro, and their therapeutic applications in the treatment of a variety of conditions, including cancer, tumors or neoplasias, as well as viral, retroviral, autoimmune, and autoimmune-type diseases. The present invention also relates to vectors, cell lines, recombinant DNA molecules encoding human .beta.2 microglobulin or Class I MHC molecules in soluble and insoluble form, and methods of producing same.

REFERENCES:
ATCC Catalogue pp. 47, 48, 72 & 73 (1992).
Osband et al Immunology Today 11(6):193-195 (1990).
Basse et al. Cancer Immunol. Immunother. 34:221-227 (1992).
Levy et al. Int. Imm. 2(10):995-1002 (1990).
Angelichio et al NAR 19(18):5037-5043 (1991).

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