In vitro activation of cytotoxic T cells

Details In vitro activation of cytotoxic T cells In vitro activation of cytotoxic T cells

1996-06-24

1998-10-27

Tsang, Cecila J.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Insect cell, per se

435346, 530394, C12N 506, A61K 3514

Patent

active

058277374

ABSTRACT:
The present invention relates to a rational, elegant means of producing, loading and using Class I molecules to specifically activate CD8 cells in vitro, and their therapeutic applications in the treatment of a variety of conditions, including cancer, tumors or neoplasias, as well as viral, retroviral, autoimmune, and autoimmune-type diseases. The present invention also relates to vectors, cell lines, recombinant DNA molecules encoding human .beta.2 microglobulin or Class I MHC molecules in soluble and insoluble form, and methods of producing same.

REFERENCES:
Levy, F and Kvist, S. International Immunology. 2(10): 995-1002, Oct. 1990.
Jackson, MR et al. Proc. Natl. Acad. Sci. (USA). 89: 12117-12121, Dec. 1992 .

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