In vitro activation of cytotoxic T cells

Details In vitro activation of cytotoxic T cells In vitro activation of cytotoxic T cells

1998-06-24

1999-12-14

Saunders, David

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

42419711, 4242361, 514 2, 514 21, 435348, A61K 39385, A61K 3802, C12N 506

Patent

active

060013656

ABSTRACT:
The present invention relates to a rational, elegant means of producing, loading and using Class I molecules to specifically activate CD8 cells in vitro, and their therapeutic applications in the treatment of a variety of conditions, including cancer, tumors or neoplasias, as well as viral, retroviral, autoimmune, and autoimmune-type diseases. The present invention also relates to vectors, cell lines, recombinant DNA molecules encoding human .beta.2 microglobulin or Class I MHC molecules in soluble and insoluble form, and methods of producing same.

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