In-vial deposition of 7-(dimethylaminomethylene)amino-9.alpha.-m

Details In-vial deposition of 7-(dimethylaminomethylene)amino-9.alpha.-m In-vial deposition of 7-(dimethylaminomethylene)amino-9.alpha.-m

1986-05-14

1988-12-20

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3140

Patent

active

047925663

ABSTRACT:
There is disclosed a process for the in-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxymitosane in sterile unit dosage form. A solution of this compound is introduced into a sterile vial in a solution of tertiary-butanol. The tertiary-butanol is then removed, e.g., by evaporation or lyophilization, and the vial is closed by appropriate means. The thus deposited material can contain up to 0.5 mole equivalent of tertiary-butanol as a hemi-solvate and is very stable to heat.

REFERENCES:
patent: 4487769 (1984-12-01), Vyas et al.

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