In utero oral nucleic acid immunization

Details In utero oral nucleic acid immunization In utero oral nucleic acid immunization

2005-09-20

2005-09-20

Crouch, Deborah (Department: 1632)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S227100, C424S228100, C424S229100, C424S230100, C424S231100, C424S093200

Reexamination Certificate

active

06946448

ABSTRACT:
Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.

REFERENCES:
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Gerdts, et al., “Oral DNA Vaccination In Utero Induces Mucosal Immunity and Immune Memory in the Neonate,”J. Immunol.,168:1877-1885,(2002).
Le Potier, et al., “Study of the delivery of the gD gene of pseudorabies virus to one-day-old piglets by adenovirus or plasmid DNA as ways to by-pass the inhibition of immune response by colostral antibodies,”Vet. Microbiol 55:75-80(1997).
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Van Drunen Littel-van den Hurk, et al., “Immunization of Neonates with DNA Encoding a Bovine Herpesvirus Glycoprotein Is Effective in the Presence of Maternal Antibodies,”Viral Immunology, 12:67-77,(1999).
Watts, et al. “Fetal immunization of baboons induces a fetal-specific antibody response,”Nature Med., 5:427-430 (1999).
Denis et al., “Vaccination with Plasmid DNA Encoding Mycobacterial Antigen 85A Stimulates a CD4+and CD8+T-Cell Epitopic Repertoire Broader Than That Stimulated by Mycobacterium Tuberculosis H37Rv Infection,” Infection and Immunity, 66(4):1527-1533 (1998).
Fu et al., “Dose Dependence of CTL Precursor Frequency Induced by a DNA Vaccine and Correlation with Protective Immunity Against Influenza Virus Challenge,” The Journal of Immunology, 162:4163-4170 (1999).
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