In-situ preservation (ISP) bridge method and solution for...

Details In-situ preservation (ISP) bridge method and solution for... In-situ preservation (ISP) bridge method and solution for...

2007-01-09

2011-11-29

Saucier, Sandra (Department: 1657)

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

C435S001200

Reexamination Certificate

active

08067150

ABSTRACT:
A method for rapid, in-situ flushing of organs of a non-heart beating donor, and solutions for carrying out the flushing, are provided. The method initiates organ preservation, and the solutions are formulated to counteract basic mechanisms of ischemic cell injury, and to activate known biochemical survival pathways in the cell. Viability of the organ for transplant is thus maintained.

REFERENCES:
patent: 7005253 (2006-02-01), Polyak
patent: 2004/0053205 (2004-03-01), Potts et al.
patent: WO 02/30452 (2002-04-01), None
Dubey et al., “Anti-inflammatory action of diltiazem in patients with unstable angina”, Postgrad. Med. J. 82 : 594-597 (2006).

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