Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2007-01-23
2008-12-09
Barts, Samuel A (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C568S448000
Reexamination Certificate
active
07462742
ABSTRACT:
An in situ or one-pot process for the preparation of the compounds of formula (I) uses a compound of general formula (I):and includes:a) the hydrogenation of a nitrile group of the compound of general formula (II):in which R1to R4 are especially H or alkyl and n varies from 0 to 4, in the presence of a hydrogenation catalyst, a methylating agent and an organic acid as solvent, and at a temperature Ta below the initiation temperature of a reductive amination reaction, to give a primary amine from the nitrile group; andb) the reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb above Ta, to give the dimethylated amine of general formula (I) by activation of the methylating age.
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Yardley et al., “2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine Derivatives: Synthesis and Antidepressant Activity.”J. Med. Chem.33(1990): 2899-2905.
Burgos Alain
Dambrin Valéry
Lucet Denis
Poirier Patricia
Tonnel Jacques
Barts Samuel A
Merchant & Gould P.C.
ZaCh System
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