Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1992-06-30
1993-11-30
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424488, 514779, 536 3, 604 51, 604 56, A61F 202, A61K 914, A61K 4736, C08B 3704
Patent
active
052663264
ABSTRACT:
A method of modifying salts of alginic acid in situ for prevention and treatment of various intra-articular and extra-articular (spine) complications modifies the alginate in situ to an insoluble gel. This in situ modification provides a final product which can be compressed within the intra-articular space thus remaining localized. The modified material can have varied mechanical strengths and thus varied degradation times and can serve as a matrix for localizing and slowly releasing therapeutic agents. The modified material is biocompatible and biodegradable, thus requiring no reoperation for removal.
REFERENCES:
patent: 4572906 (1985-02-01), Sparkes et al.
patent: 4994277 (1991-02-01), Higham et al.
patent: 5093319 (1992-03-01), Higham et al.
Aberman Harold M.
Barry James J.
Higham Paul A.
Akers Lawrence C.
Augustin Raymond W.
Azpuru C.
Page Thurman K.
Pfizer Hospital Products Group Inc.
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