In-situ hybridization probes for identification and banding of s

Details In-situ hybridization probes for identification and banding of s In-situ hybridization probes for identification and banding of s

1993-06-01

1996-07-23

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 536 243, 536 2431, C12P 1934, C12Q 168, C07H 2104

Patent

active

055388698

ABSTRACT:
The invention relates to novel primer sets useful in preparing DNA probes specific for any chromosome or part of a chromosome, particularly human chromosomes. The DNA probes so produced may be used to paint individual chromosomes or portions of chromosomes in metephase cell spreads and in interphase nuclei. When used to paint chromosomes in metephase spreads, R-bands are readily detectable. The method is sensitive and has been shown to paint R-bands on chromosomes pieces having as few as several hundred kilobases.

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