In situ dissolution of alginate coatings of biological tissue tr

Details In situ dissolution of alginate coatings of biological tissue tr In situ dissolution of alginate coatings of biological tissue tr

1994-03-08

1996-05-07

Krass, Frederick

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424424, 424426, 435 11, 435182, 623 11, A61F 200

Patent

active

055143776

ABSTRACT:
A method for in situ dissolution of an alginate coating from transplants containing biological tissue cores by administering to a transplant's recipient a physiologically acceptable chelating agent in an amount sufficient to dissolve the alginate coating. The method allows in situ removal of the coating and deactivation of the transplant by rejection of its core by the host immune system without the necessity to perform a surgery.

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Thomas M. S. Chang, Living Cells and Microorganisms Immobilized by Microencapsulation Inside Artificial Cells, Fundamentals of Animal Cell Encapsulation and Immobilization, Chapter 8, pp. 183-196.
Wilbert M. Fritschy, et al., Effect of Alginate-Polylysine-Alginate Microencapsulation on In Vitro Insulin Release from Rat Pancreatic Islets, Diatetes, vol. 40, (Jan. 1991), pp. 37-43.

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