In situ activation of microcapsules

Details In situ activation of microcapsules In situ activation of microcapsules

1998-05-15

2000-08-08

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424423, 424450, 4284022, 42840221, 264 41, 264 43, 264 432, 264 433, 514951, A61K 950

Patent

active

060998644

ABSTRACT:
Disclosed are microcapsules comprising a polymer shell enclosing two or more immiscible liquid phases in which a drug, or a prodrug and a drug activator are partitioned into separate phases, or prevented from diffusing out of the microcapsule by a liquid phase in which the drug is poorly soluble. Also disclosed are methods of using the microcapsules for in situ activation of drugs, where upon exposure to an appropriate energy source the internal phases mix and the drug is activated in situ.

REFERENCES:
patent: 4532123 (1985-07-01), Gardner et al.
patent: 4898734 (1990-02-01), Mathiowitz et al.
patent: 4933185 (1990-06-01), Wheatley et al.
patent: 5417982 (1995-05-01), Modi
patent: 5433955 (1995-07-01), Bredehorst et al.
patent: 5470582 (1995-11-01), Supersaxo et al.

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