Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1996-07-22
1998-08-04
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424490, 514919, B01J 1306, A61K 950, A61K 952
Patent
active
057889759
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a method for improving the lasting properties of an odour. More precisely, it relates to odoriferous compositions with improved lasting properties as well as to methods for preparing them and their mode of use.
Odoriferous products or mixtures within the meaning of the invention are understood to mean all products perceived as such by man or animals. Thus, the invention relates equally well to the domain of perfumes and products including an odoriferous composition or ingredient of which it is desired to prolong and control the pleasant olfactory effect and to that of repellants, in particular repellants for animals, where it is of interest to have available substances which are effective for a period of time which is as long as possible. It also concerns the domain of pheromones which are substances specifically sensed by certain animals and of which the effect on them is therefore assimilable to that of an odour.
Repellants for animals are formulations of products of which the odour repels the animals. Among known products having this effect, extracts of mustard are the most used. Commercial formulations present the drawback of having an effect very limited in time, and therefore require very frequent applications to ensure permanent efficacy (daily application).
It is known that, in the domain of plant protective formulations but also in that of odoriferous compositions, one often resorts to mixtures of active compounds and additives having for a role to ensure arrangement of the active products. Very often, the active product is a molecule or a mixture of hydrophobic molecules. For obvious reasons of facility of use, it is very useful to formulate the active product so as to render it dispersible or soluble in an aqueous medium. Among the methods enabling such an object to be attained, the use of surfactants often allows a good dispersibility and therefore facilitates use of the active ingredient.
One of the characteristics often sought in such formulations is the lasting property of the active ingredient. One manner of obtaining it often consists in using an excess of compounds. Other methods have been used, in particualr in the plant protection domain such as encapsulation by polymer (of coacervation type for example: cf. for example ANPP Second International Conference on Agricultural Pests "The microencapsulation of plant protection products", V. VIDEAU and S. MEGHIR, page 371). These techniques generally present the drawback of being difficult and expensive to carry out. Moreover, the release of the active ingredient from the capsule is not well controlled and is generally governed by the destruction of the capsule, either chemically (hydrolysis), or mechanically.
Independently of the dispersing effect, the surface-active molecules make it possible in certain cases to protect and vectorize then release in controlled manner active molecules, by using microcapsules formed by a supramolecular association of the surface-active molecules. The most current example is that of liposomes used in cosmetics and in the biomedical domain. These liposomes correspond to an arrangement in vesicles (uni-lamellar or multi-lamellar) of dimensions included between some hundreds of Angstroms and several microns. These vesicles are, in the case of liposomes, obtained from phospholipidic molecules (extracted for example from soja or egg). These liposomes are capable of encapsulating lipophilic or even hydrophilic active molecules and thus of performing the functions of vectorization and release envisaged.
French Patent FR 2 689 418 describes a method which, thanks to resorting to a step of shearing of a lamellar crystal-liquid phase, makes it possible to prepare microcapsules of controlled size, not only from lipidic surfactants capable of forming liposomes but also from different anionic or non-ionic surfactants and proposes encapsulation of substances, particularly biological ones, in these capsules.
European Patent Application EP 0 388 239 describes the use of a medium containing a st
REFERENCES:
patent: 4808408 (1989-02-01), Baker et al.
patent: 4822614 (1989-04-01), Rodero et al.
"ANPP", B. Videau and S. Meghir, Dec. 1990, pp. 371-383.
Laversanne Rene
Roux Didier
Capsulis
Kulkosky Peter F.
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