Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Patent
1993-07-14
1995-06-06
Niebling, John
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
4351734, 4351735, 4351736, 4351737, 935 85, 935 93, G12N 1500, G12N 1509, C12N 1300
Patent
active
054222729
ABSTRACT:
A new quickly replaceable electrode assembly for electroporation that also provides the functions of a pipette, capable of sucking up samples; applying extremely high electric field strength to samples at lower, safer voltages due to close spacing of the electrode plates; and expelling samples quickly and completely; along with a quick-connect receptacle for the electrode assembly. New methods are detailed for construction of electrode assemblies, providing electric current, monitoring characteristics of electric pulses delivered to samples, and space saving hand held units using low voltage D.C., A.C. line, and piezoelectric power supplies, with peak current delivered indicators are disclosed.
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E. Neumann, M. Schaefer-Ridder, Y. Wang and P. H. Hofschneider. Gene Transfer into Mouse Lyoma Cells by Electroporation in High Electric Fields. EMBO J.1(7) pp. 841-845 1982.
E. Tekle, R. Dean Astumian, and P. Chock. Electroporation by Using Bipolar Oscillating Electric Field: An Improved Method for DNA Transfection of NIH 3T3 Cells. Proc. Nat'l Acad. Sci. USA vol. 88 pp. 4230-4234 May 1991.
Biondo, Jr. John V.
Papp Andrew A.
Niebling John
Papp Andrew A.
Starsiak Jr. John S.
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