Improvements in redox systems for brain-targeted drug delivery

Details Improvements in redox systems for brain-targeted drug delivery Improvements in redox systems for brain-targeted drug delivery

1987-12-30

1991-03-26

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, 424488, 514778, 514965, A61K 3144, A61K 31445, A61K 922, C07D21382

Patent

active

050029355

ABSTRACT:
Inclusion complexes of hydroxypropyl-.beta.-cyclodextrin with the reduced biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine.revreaction.pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation. The reodox inclusion complexes also provide a means for decreasing initial drug concentrations in the lungs after administration of the systems, leading to decreased toxicity. In selected instances, complexation results in substantially improved water solubility of the redox systems as well.

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