Improvement in the method of NMR imaging employing a manganese I

Details Improvement in the method of NMR imaging employing a manganese I Improvement in the method of NMR imaging employing a manganese I

1989-07-14

1991-02-19

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

546 6, 546261, 436 96, A61K 4900, A61K 3144, G01N 3315

Patent

active

049942590

ABSTRACT:
Manganese(II) chelates of N,N'-bis-(pyridoxal)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-1,2-cycloalkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-1,2-arylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-alkylenediamine-N-acetic acids, N,N'-bis-(pyridoxal)-1,2-cycloalkylenediamine-N-acetic acids, N,N'-bis-(pyridoxal)-1,2-arylenediamine-N-acetic acids, and their salts are highly stable, superior NMRI contrast agents. They maintain the manganese(II) ion in the +2 valence state. Preferred contrast agents are manganese(II) ion chelates of N,N'-bis-(pyridoxal)ethylenediamine-N,N'-diacetic acid, N,N'-bis-(pyridoxal)trans-1,2-cyclohexylenediamine-N,N'-diacetic acid, and the salts and esters thereof.
Novel chelate forming compounds are the N,N'-bis-(pyridoxal)-1,2-cycloalkylenediamine-N,N'-diacetic acids and N,N'-bis-(pyridoxal)1,2-arylene-diamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-alkylenediamine-N-acetic acids, N,N'-bis(pyridoxal)-1,2-cycloalkylenediamine-N-acetic acids, N,N'-bis-(pyridoxal)-1,2-arylenediamine-N-acetic acids, and their salts and esters.

REFERENCES:
patent: 4877600 (1989-10-01), Bonnemain et al.
patent: 4880007 (1989-11-01), Sadler et al.
patent: 4933456 (1990-06-01), Rocklage et al.
Chem. Abstracts, vol. 100 (20) Abst. 100: 162,723-y, May 14, 1984.
Chem. Abstracts, vol. 103 (6), Abst. 103: 43589m, Aug. 12, 1985.

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