Improved process for preparing polymyxin B/dextran conjugates

Details Improved process for preparing polymyxin B/dextran conjugates Improved process for preparing polymyxin B/dextran conjugates

1995-05-25

1997-11-25

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, 530322, A61K 3810, C07K 500

Patent

active

056913044

ABSTRACT:
An improved process for producing a water-soluble polymyxin B/dextran conjugate comprises the step of reacting polymyxin B or pharmaceutically acceptable salt thereof with dextran in an aqueous media at a pH of about 9.3 to 10.

REFERENCES:
patent: 5177059 (1993-01-01), Handley et al.
Biotechnology Therapeutics, "Inhibition of Polysaccharide-Induced TNF-Alpha Production by Semisynthetic Polymyxin-B Conjugated Dextran", vol. 5, No. 3-4, 1994-1995, pp. 137-162, XP002015878, Coyne, C.P., et al.

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