Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Stent structure
Patent
1997-01-23
1999-09-28
Clarke, Robert A.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Arterial prosthesis
Stent structure
435372, A61F 206
Patent
active
059579722
ABSTRACT:
Autologous and synthetic vascular implants that possess an external monolayer of endothelial cells genetically modified to express at least one of a number of therapeutic agents useful for the inhibition of smooth muscle cell proliferation are provided. In the preferred embodiment of this invention, the endothelial cells coating the implant are genetically-modified to express and secrete the protein interferon-gamma. The use of such an implant in vascular and heart surgeries would substantially increase both the patency of the graft and the rate of surgical success by inhibiting the expansive growth of the vessel or heart lumen in response to surgical damage, which is a major cause of graft failure.
REFERENCES:
patent: 4820626 (1989-04-01), Williams et al.
patent: 4883755 (1989-11-01), Carabasi et al.
patent: 5035708 (1991-07-01), Alchas et al.
patent: 5096705 (1992-03-01), Goeddel et al.
patent: 5131907 (1992-07-01), WIlliams et al.
patent: 5194373 (1993-03-01), Williams et al.
patent: 5208019 (1993-05-01), Hansson et al.
patent: 5230693 (1993-07-01), Williams et al.
patent: 5312380 (1994-05-01), Alchas et al.
patent: 5336615 (1994-08-01), Bell et al.
patent: 5372945 (1994-12-01), Alchas et al.
patent: 5441539 (1995-08-01), Alchas et al.
patent: 5674722 (1997-10-01), Mulligan et al.
Friesel et al, "Inhibition of Endothelial Cell Proliferation by Gamma-Interon" J. Cell Biol. 104:689-96, Mar. 1987.
Berger, "Healing of Arterial Prostheses in Man: Its Incompleteness", supra.
Feldman et al., "Low Efficiency of Percutaneous Adenovirus-Mediated Arterial Gene Transfer in the Atherosclerotic Rabbit", J Clin Invest 1995;95:2662-71.
Fishman, "Endothelium" A Distributed Organ of Diverse Capabilities, Annl of NY Acad of Sci 1982:1-8.
Glasberg et al., "Cultured Endothelial Cells Derived From Human Iliac Arteries", In Vitro 1982;18:859-66.
Graham et al., "Cultured Autogenous Endothelial Cell Seeding of Vascular Prosthetic Grafts", Surg Forum 1979;30:204-6.
Graham et al., "Expanded Polytetrafluorethylene Vascular Prostheses Seeded with Enzymatically Derived and Cultured Canine Endothelial Cells", Surgery 1982;91:550-9.
Hansson et al., "Interferon-.gamma. Inhibits Arterial Stenosis After Injury", Circ 1991;84:1266-1272.
Hansson et al., "Interferon-.gamma. Regulates Vascular Smooth Muscle Cell Proliferation and Ia Expression in Vivo and In Vitro", Circ Res 1988;63:712-719.
Herring et al., "A Single and Staged Technique for Seeding Vascular Grafts with Autogenous Endothelium", Surgery 1978;84:498-504.
Jaffe et al., "Culture of Human Endothelial Cells Derived From Umbilical Veins", J Clin Invest 1973;52:2745-56.
Jaffe et al., "Synthesis of Antihemophilia Factor Antigen by Cultured Human Endothelial Cells", J Clin Invest 1973;55:2757-64.
Jarrell et al, "Human Adult Endothelial Cell Growth in Culture", J. Vasc. Surg 1984;1:757-765.
Lewis, "Endothelium in Tissue Culture", Am J Anat 1922;30:39-59; and Jaffe et al., "Culture of Human Endothelial Cells Derived From Umbilical Veins", J Clin Invest 1973;52:2745-56.
Mann et al., "Construction of a Retrovirus Packaging Mutant and Its Use to Produce Helper-Free Defective Retrovirus," Cell 1983;33:153-159.
Sauvage et al., "Interspecies Healing of Porous Arterial Prostheses", Arch Surg 1974;109:698-705.
Simon et al., "Adenovirus-Mediated Gene Transfer of the CFTR Gene to Lungs of Nonhuman Primates: Toxicity Study", Hum Gen Ther 1993;4:771-80.
Von der Leyen et al., "Gene Therapy Inhibiting Neointimal Vascular Lesion: In vivo Transfer of Endothelial Cell Nitric Oxide Synthase Gene", Proc Natl Acad Sci USA 1995;92:1137-47.
Watkins et al., "Adult Human Saphenous Vein Endothelial Cells: Assessment of Their Reproductive Capacity for Use in Endothelial Seeding of Vascular Prostheses", J Surg Res 1984;36:588-96.
Wilson et al., "Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells", Science 1989;244:1344-1346.
Williams, "Endothelial Cell Transplantation", Cell Trans. 1995;4:401-409.
Wu et al., "Restoration of Prostacyclin Synthesis by Transfer of PGHS cDNA", Adv Prostagl Thrombox Leukotri 1994;23:377-80.
Wu et al., "Role of Endothelium in Thrombosis and Hemostasis", Annu Rev Med 1996;47:315-31.
Stopeck Alison
Williams Stuart K.
Arizona Board of Regents on Behalf of the University of Arizona
Clarke Robert A.
Durando Antonio R.
LandOfFree
Implants possessing a surface of endothelial cells genetically-m does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Implants possessing a surface of endothelial cells genetically-m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Implants possessing a surface of endothelial cells genetically-m will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-697276