Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2006-03-14
2006-03-14
Crouch, Deborah (Department: 1632)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S093210, C435S366000, C435S368000, C435S377000
Reexamination Certificate
active
07011828
ABSTRACT:
The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof.This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.
REFERENCES:
patent: 2002263199 (2001-11-01), None
patent: WO 99/11758 (1999-03-01), None
patent: WO 99/32606 (2000-11-01), None
patent: WO 01/68815 (2001-09-01), None
Li, M. et al. Generation of Purified Neural Precursors from Embryonic Stem Cells by Lineage Selection. Current Biology. 1998, vol. 8, pp. 971-0974.
Martinez-Serrano, A. et al. CNS-Derived Neural Progenitor Cells for Gene Transfer of Nerve Growth Factor to the Adult Rat Brain: Complete Rescue of Axotomized Cholinergic Neurons after Transplantation into the Septum. J. Neurosci. 1995, vol. 1, 5668-5680.
Fricker, R. et al. Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain. J. Neurosci. 1999, vol. 19, pp. 5990-6005.
Svendsen, C.N. et al. Increased Survival of Rat EGF-Generated CNS Precursor Cells using B27 Supplemented Medium. Experimental Brain Res. 1995, Vo. 102, pp. 407-414.
Reubinoff, B. E., et al., “Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro”,Nature Biotechnology, Nature Pub. Co., New York, NY, 1B(4): 399-404, (2000), XP002195338.
R.A. Pedersen, “Studies of in vitro Differentiation with Embryonic Stem Cells”,Reprod. Fertil. Dev., vol. 6, pp. 543-552, (1994).
P.D. Rathjen, et al., “Properties and Uses of Embryonic Stem Cells: Prospects for Application to Human Biology and Gene Therapy”,Reprod. Fertil. Dev., vol. 10, pp. 31-47, (1998).
T. Mujtaba, et al., “Lineage-Restricted Neural Precursors Can Be Isolated from Both the Mouse Neural Tube and Cultured ES Cells”,Developmental Biology, vol. 214, pp. 113-127, (1999).
O. Brustle, et al., “Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants”,Science, vol. 285, pp. 754-756, (1999).
C.N. Svendsen, et al., “New Prospects for Human Stem Cell Therapy in the Nervous System”,Trends in Neuroscience, vol. 22, No. 8, pp. 357-364, (1999).
J. Thomson, et al., “Neural Differentiation of Rhesus Embryonic Stem Cells”Acta Pathologica, Microbiologica, et Immunological Scandinavica, vol. 106, pp. 149-157, (1998).
M.J. Shamblott, et al., “Derivation of pluripotent stem cells from cultered human primordial germ cells”,Proc. Natl. Acad. Sci, USA, 95: 13726-13731 (1998).
Sang-Hun Lee, et al., “Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells”,Nature Biotechnology, 18: 675-679 (2000).
Diana L. Clarke, et al., “Generalized Potential of Adult Neural Stem Cells”,Science, 288: 1660-1663 (2000).
Ben-Hur Tamir
Pera Martin Frederick
Reubinoff Benjamin Eithan
Crouch Deborah
ES Cell International Pte. Ltd.
Scully Scott Murphy & Presser
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