Implantable systems and methods for monitoring myocardial...

Surgery – Diagnostic testing – Cardiovascular

Reexamination Certificate

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Reexamination Certificate

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08005533

ABSTRACT:
Embodiments of the present invention relate to implantable systems, and methods for use therewith, for assessing a patients' myocardial electrical stability. Implanted electrodes are used to obtain an electrogram (EGM) signal, which is used to identify periods when the patient experiences T-wave alternans. Additionally, the EGM signal is used to determine whether premature ventricular contractions (PVCs) cause phase reversals of the T-wave alternans. The patient's myocardial electrical stability is assessed based on whether, and in a specific embodiment the extent to which, PVCs cause phase reversals of the T-wave alternans. This abstract is not intended to be a complete description of, or limit the scope of, the invention.

REFERENCES:
patent: 6915156 (2005-07-01), Christini et al.
patent: 2005/0004608 (2005-01-01), Bullinga
patent: 2006/0116592 (2006-06-01), Zhou et al.
patent: 2006/0116596 (2006-06-01), Zhou et al.
patent: 2005006956 (2005-01-01), None
Narayan et al., “T-wave Alternans Phase Following Ventricular Extrasystoles Predicts Arrhythmia-Free Survival,” Heart Rhythm, vol. 2, No. 3, Mar. 2005: 234-241.
Rubenstein et al., “Premature Beats Elicit a Phase Reversal of Mechanoelectrical Alternans in Cat Ventricular Myocytes: A Possible Mechanism for Reentrant Arrhythmias,” Circulation. 1995;91:2001-214.
Brugada et al., “Significance of Ventricular Arrhythmias Initiated by Programmed Ventricular Stimulation: The Importance of the Type of Ventricular Arrhythmia Induced and the Number of Premature Stimuli Required,” Circulation. 1984;69:87-92.
Christini et al., “Endocardial Detection of Repolarization Alternans,” IEEE Transaction on Biomedical Engineering, vol. 50, No. 7, Jul. 2003: 855-862.

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