Implantable signal amplifying circuit for...

Surgery – Diagnostic testing – Detecting brain electric signal

Reexamination Certificate

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C330S260000

Reexamination Certificate

active

08086305

ABSTRACT:
An implantable microvolt-level signal amplifying circuit may be used for resolving electrical signals generated by nerves in the presence of larger amplitude signals generated by muscles, the heart, or external noise sources. The circuit has a low-noise, high Common Mode Rejection Ratio (CMRR) preamplifier, followed by a cascade of stages, which provide filtering and further amplification of the neural signal. The band-pass amplifying circuit can also present high Power Supply Rejection Ratio (PSRR). The output is offset-compensated by a DC restoration stage. Nerve protection circuitry minimizes or blocks DC current flow through the input terminals in the event of semiconductor failure in the preamplifier. The circuit may be incorporated onto a common monolithic circuit with follow-up circuitry for controlling Functional Electrical Stimulation (FES) devices.

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patent: 6084476 (2000-07-01), Hamanishi et al.
patent: 6587725 (2003-07-01), Durand et al.
Papathanasiou et al., An Implantable CMOS Signal Conditioning System for Recording Nerve Signals with Cuff Electrodes, IEEE International Symposium on Circuits and Systems, May 2000, 281-284, Geneva, Switzerland.
K.H. Kim and S.J. Kim; “Noise Characteristic design of CMOS source follwer and Voltage amplifier for active semiconductor microelectrodes for neural signal recording”; Medical & Biological Engineering & Computing 2000, vol. 38: pp. 469-472.

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