Implantable, self-regulating mechanochemical insulin pump

Surgery – Controlled release therapeutic device or system – Implanted dynamic device or system

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

604141, 424423, A61K 922

Patent

active

050628410

ABSTRACT:
An implantable pump for the delivery of insulin to a mammal has a biocompatible housing which supports an aqueous-swellable glucose-sensitive member and a chamber containing a pharmaceutically acceptable insulin composition. The aqueous-swellable member is exposed to the body fluids which surround the pump when it is implanted; it initiates an insulin pumping cycle by swelling in response to an increase in blood glucose level and terminates an insulin pumping cycle by deswelling in response to the decrease in blood glucose level. When the glucose-sensitive aqueous-swellable member swells in response to an increase in blood glucose level, it generates a hydraulic force which causes insulin composition to be expelled from the chamber through a pressure-sensitive one way valve. The valve seals the chamber when the hydraulic force is withdrawn by deswelling of the glucose-sensitive aqueous-swellable member.

REFERENCES:
patent: 3995632 (1976-12-01), Nakano et al.
patent: 4209014 (1980-06-01), Sefton
patent: 4717566 (1988-01-01), Eckenhoff et al.
patent: 4723958 (1988-02-01), Pope et al.
patent: 4820273 (1989-04-01), Reinke
Albisser, "Devices for the Control of Diabetes Meltius," Proc. IEEE (1979), 67:1308-1319.
Kim et al., "Self-Regulating Insulin Delivery Systems. 1. Synthesis and Characterization of Glycosylated Insulin," J. Controlled Release (1984), 1:57-66.
Kim et al., "Self-Regulating Insulin Delivery Systems. II. In Vitro Studies," J. Controlled Release (1984), 1:67-77.
Kim. et al., "Self-Regulating Insulin Delivery Systems. III. In Vivo Studies," J. Controlled Release (1984), 2:143-152.
Fischel-Ghodsian et al., "Enzymatically Control Drug Delivery," Proc. Natl. Acad. Sci. USA (1988), 85:2403-2406.
Heller et al., "A Bioerodible Self-Regulated Insulin Delivery Device," Proc. 13th Intl. Symp., Controlled Release of Bioactive Materials, 37-8 (1986).
Kost et al., "Glucose-Sensitive Membranes Containing Glucose Oxidase: Active Swelling, and Permeability Studies," J. Biomed. Mater. Res. (1985), 19:1117-11.
Albin et al., "Theoretical and Experimental Studies of Glucose Sensitive Membranes," J. Controlled Release (1987), 6:267-291.
Ishihara et al., "Glucose Induced Permeation Control of Insulin through a Complex Membrane Consisting of Immobilized Glucose Oxidase and a Poly(amine)," Polymer Journal (1984), 16:625-631.
Ishihara et al., "Glucose-Responsive Insulin Release from Polymer Capsule," J. of Polymer Science: Polymer Letters Ed. (1986), 24:413-417.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Implantable, self-regulating mechanochemical insulin pump does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Implantable, self-regulating mechanochemical insulin pump, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Implantable, self-regulating mechanochemical insulin pump will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-496143

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.