Surgery – Controlled release therapeutic device or system – Implanted dynamic device or system
Patent
1989-11-14
1991-11-05
Pellegrino, Stephen C.
Surgery
Controlled release therapeutic device or system
Implanted dynamic device or system
604141, 424423, A61K 922
Patent
active
050628410
ABSTRACT:
An implantable pump for the delivery of insulin to a mammal has a biocompatible housing which supports an aqueous-swellable glucose-sensitive member and a chamber containing a pharmaceutically acceptable insulin composition. The aqueous-swellable member is exposed to the body fluids which surround the pump when it is implanted; it initiates an insulin pumping cycle by swelling in response to an increase in blood glucose level and terminates an insulin pumping cycle by deswelling in response to the decrease in blood glucose level. When the glucose-sensitive aqueous-swellable member swells in response to an increase in blood glucose level, it generates a hydraulic force which causes insulin composition to be expelled from the chamber through a pressure-sensitive one way valve. The valve seals the chamber when the hydraulic force is withdrawn by deswelling of the glucose-sensitive aqueous-swellable member.
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Pellegrino Stephen C.
Rafa Michael
The Regents of the University of California
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