Implantable polymer hydrogel for therapeutic uses

Details Implantable polymer hydrogel for therapeutic uses Implantable polymer hydrogel for therapeutic uses

1996-10-16

1999-01-26

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424 7808, 424487, 526199, 526200, 623 11, 523113, A61K 31785, A61K 4732, A61L 3100

Patent

active

058635513

ABSTRACT:
The hydrogel is a copolymer of an N-substituted methacrylamide or acrylamide, a cross-linking agent and a complex sugar or derivative, a tissue adhesion peptide or a polymer conjugate with antibodies, the polymer being heterogeneous, elastically deformable and having an equilibrium water content of at least about 80%. It can be used for tissue regeneration and for organ repair, for example, in the developing and adult nervous system.

REFERENCES:
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Harvey et al. Brain Res., 671,119,1995.
Bellamkonda et al. Hydrogel-based 3-dimensional matrix for neural cells, J. Biomed Mat. Res. 29, 663-671, 1995.
Krewson et al. Cell aggregatyion and neurite growth in gels of extracellular matrix molecules, Biotechnol. Bioeng. 43, 555-562, 1994.
Wald et al. Cell seeding in porous transplantation, Biomat. 14, 270-278,1993.
Woerly et al. Neurosci. Lett. 205, 197-201, 1996.

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