Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2011-03-29
2011-03-29
Henley, III, Raymond J (Department: 1614)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S423000, C424S443000, C424S484000, C424S486000
Reexamination Certificate
active
07914805
ABSTRACT:
An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region comprising a polymer. The polymeric release region is treated with a radiation dose that is effective to substantially increase the cumulative release of the therapeutic agent subsequent to administration to a patient. The polymeric release region can be, for example, (a) a carrier region that comprises the therapeutic agent or (b) a barrier region that is disposed over a therapeutic-agent-containing region that comprises the therapeutic agent. The present invention is further directed to methods of forming such medical devices, methods of releasing a therapeutic agent within a patient using such medical devices, and methods of modulating the release of a therapeutic agent from such medical devices.
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Richard Robert E.
Schwarz Marlene C.
Bonham David B.
Boston Scientific Scimed Inc.
Henley, III Raymond J
Mayer & Williams PC
Park Keum J.
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