Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Reexamination Certificate
2005-05-03
2005-05-03
Isabella, David J. (Department: 3738)
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
C604S265000, C427S002100, C422S028000
Reexamination Certificate
active
06887270
ABSTRACT:
Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.
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Dayton Peter L.
Geitz Kurt
Miller Kathleen M.
Sahatjian Ronald A.
Sydney Gregory T.
Bonham, Esq. David B.
Boston Scientific SciMed, Inc.
Isabella David J.
Mayer Fortkort & Williams PC
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