Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving glucose or galactose
Patent
1987-12-30
1990-06-19
Nguyen, Nam X.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving glucose or galactose
435 4, 435 27, 435288, 435290, 435291, 435817, 128635, C12Q 154, A61B 505
Patent
active
049353454
ABSTRACT:
A biochemical sensor is provided for measuring the concentration of a chemical dissolved within a fluid by providing a differential voltage proportional to a temperature differential resulting from the heat evolved from the enzymatic reaction of the chemical under test. The biochemical sensor is formed by depositing thin films of two dissimilar metals upon a substrate using microelectronic fabrication techniques. A multiplicity of thermocouple junctions are created at the intersections of the two dissimilar metal films, and the resulting series-connected thermocouple junctions are alternately designated sensing and reference junctions. The sensing junctions, but not the reference junctions, are covered by an enzyme, catalyst, or other species for initiating a chemical reaction involving the chemical under test, giving rise to a temperature differential between the sensing and reference junctions proportional to the concentration of the chemical under test. The biochemical sensor may be implanted within a human body for continuously monitoring concentrations of glucose or other chemicals present within the bloodstream.
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Guilbeau Eric J.
Towe Bruce C.
Arizona Board of Regents
Nguyen Nam X.
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