Chemistry: molecular biology and microbiology – Apparatus – Bioreactor
Patent
1985-09-18
1987-07-14
Scott, Samuel
Chemistry: molecular biology and microbiology
Apparatus
Bioreactor
128635, 204403, 204415, 435288, C12M 134
Patent
active
046802681
ABSTRACT:
The present invention relates to a novel implantable biosensor and method for sensing products, such as hydrogen peroxide, generated from an enzymatic reaction between an analyte, like glucose, and an enzyme in the presence of oxygen. The novel implantable biosensor is uniquely equipped with an enclosed chamber for containing oxygen and can be adapted for extracting oxygen from animal tissue adjacent the container. The reservoir of oxygen contained in the enclosed chamber is supplied to the enzymatic reaction from the side of the membrane opposite the enzyme. The enclosed chamber is uniquely designed to be impermeable to substances, like liquid and cells, that possibly can interfere with the supply of the oxygen permeating through the membrane to the enzymatic reaction. Also, the implantable biosensor is designed to optically or electrically sense products generated from the enzymatic reaction which serve as a function of the analyte.
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Children's Hospital Medical Center
Flanigan Allen J.
Scott Samuel
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