Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Reexamination Certificate
2005-08-23
2005-08-23
Nasser, Robert L. (Department: 3736)
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
C600S347000, C600S365000, C204S415000
Reexamination Certificate
active
06934572
ABSTRACT:
An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
REFERENCES:
patent: 3539455 (1970-11-01), Clark, Jr.
patent: 3542662 (1970-11-01), Hicks et al.
patent: 4252123 (1981-02-01), Kimmich
patent: 4431004 (1984-02-01), Bessman et al.
patent: 4484987 (1984-11-01), Gough
patent: 4627906 (1986-12-01), Gough
patent: 4650547 (1987-03-01), Gough
patent: 4671288 (1987-06-01), Gough
patent: 4703756 (1987-11-01), Gough et al.
patent: 4759828 (1988-07-01), Young et al.
patent: 4781798 (1988-11-01), Gough
patent: 4836907 (1989-06-01), Pedersen
patent: 4890620 (1990-01-01), Gough
patent: 5007424 (1991-04-01), Ahsbahs et al.
patent: 5165407 (1992-11-01), Wilson et al.
patent: 5174291 (1992-12-01), Schoonen et al.
patent: 5190041 (1993-03-01), Palti
patent: 5322063 (1994-06-01), Allen et al.
patent: 5330634 (1994-07-01), Wong et al.
patent: 5441739 (1995-08-01), Kossovsky et al.
patent: 5476094 (1995-12-01), Allen et al.
patent: 5497772 (1996-03-01), Schulman et al.
patent: 5571166 (1996-11-01), Dinh et al.
patent: 5660163 (1997-08-01), Schulman et al.
patent: 5694932 (1997-12-01), Michel
patent: 5707502 (1998-01-01), McCaffrey et al.
patent: 5711861 (1998-01-01), Ward et al.
patent: 5791344 (1998-08-01), Schulman et al.
patent: 5999848 (1999-12-01), Gord et al.
patent: 6259937 (2001-07-01), Schulman et al.
patent: 6477395 (2002-11-01), Schulman et al.
Gough, et al.; “Two-Dimensional Enzyme Electrode Sensor for Glucose”,Analytical Chemistry, vol. 57, No. 12, pp. 2351-2357 (1985).
Adomian Gerald E.
Byers Charles L.
Colvin Michael S.
Schulman Joseph H.
Alfred E. Mann Foundation for Scientific Research
Foley & Lardner LLP
Nasser Robert L.
LandOfFree
Implantable enzyme-based monitoring system having improved... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Implantable enzyme-based monitoring system having improved..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Implantable enzyme-based monitoring system having improved... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3523333