Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1994-09-12
1996-03-26
Green, Randall
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
604 41, 607116, 4351736, A61N 130
Patent
active
055016626
ABSTRACT:
A method and apparatus are provided for introducing molecules such as genes and pharmacological compounds into living blood cells of a patient for therapeutic purposes. A device is implanted into the body of the patient for generating an electric field at a preselected location within a selected blood vessel. Preselected molecules are infused into the selected blood vessel. Simultaneously an electric signal is applied to the implanted device to repeatedly subject a quantity of blood flowing within the selected blood vessel past the preselected location to electric fields of a predetermined amplitude and duration. The parameters of the electric fields are precisely controlled in order to make the walls of preselected cells in the blood transiently permeable to permit the molecules to enter said preselected cells without killing said cells. The device can include either a pair of electrodes implanted in the blood vessel, or alternatively, an induction coil that surrounds the blood vessel. The electric signal is supplied by a power pack and the preselected molecules are infused with a supply pump.
REFERENCES:
patent: 2320462 (1943-06-01), Nawells
patent: 3978864 (1976-09-01), Smith et al.
patent: 4400178 (1984-04-01), Bussard et al.
patent: 4639244 (1987-01-01), Rizk et al.
patent: 4690130 (1987-09-01), Mirell
patent: 4801459 (1989-01-01), Liburdy
patent: 4842598 (1989-06-01), Tran
patent: 4906576 (1990-03-01), Marshall, III
patent: 4936317 (1990-06-01), MacGregor
patent: 4970154 (1990-11-01), Chang
patent: 5016615 (1991-05-01), Driller et al.
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5042975 (1991-08-01), Chien et al.
patent: 5087243 (1992-02-01), Auitall
patent: 5183456 (1993-02-01), Liboff et al.
patent: 5236413 (1993-08-01), Feiring
patent: 5246437 (1993-09-01), Abela
patent: 5273525 (1993-12-01), Hofmann
patent: 5286254 (1994-02-01), Shapland et al.
patent: 5290409 (1994-03-01), Liboff et al.
patent: 5304120 (1994-04-01), Crandell et al.
patent: 5318514 (1994-06-01), Hofmann
patent: 5389069 (1995-02-01), Weaver
patent: 5439440 (1995-08-01), Hofmann
Engineering Circuit Analysis, 3rd Ed. pp. 136-137, 526-529.
Modern Dictionary of Electronics, pp. 156, 242.
Genetronics Inc.
Green Randall
Reichle K. M.
LandOfFree
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