Implantable dosaging system

Details Implantable dosaging system Implantable dosaging system

1996-07-26

1999-04-20

Buiz, Michael

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

6048901, 604152, 604247, A61M 1100

Patent

active

058953728

DESCRIPTION:

BRIEF SUMMARY
The invention relates to an implantable dosaging system for medications, active substances, etc., which are in particular applied in the form of dissolved or suspended fluids.
Due to the fact that numerous medications act at different points of the body (ubiquitous), it is desirable to bring the said medications in a maximum targeted manner to the point or points of the organism where they are to have their intended action. In the case of systemic administration of medications acting in an ubiquitous manner, in part significant side effects can be observed. An oral administration of certain active substances is not always possible, because they are in part decomposed in the digestive tract. Thus, in many respects, there is a need to directly (intracorporal local) administer medications or active substances.
The local intracorporal administration is, however, complicated in numerous illnesses and complaints. If e.g. the medication is locally injected, said injection in almost each case must be given by trained therapists. This normally means that a doctor must be sought for each administration. In addition, most regions of the organism are difficultly accessible for a corresponding application and this more particularly applies to the skull region of the human. Thus, e.g. in certain treatments of the middle or inner ear a medication must be administered through the eardrum into the tympanic cavity. This is not only medically complicated, but also stressing for the patient.
The prior art discloses numerous implantable dosaging systems. According to DE 3639980 C1 a dosaging system comprises an implantable capsule, in which are located a medication collecting container and a pumping mechanism. An implantable catheter system with an injection port are provided for refilling the collecting container. The dosaging system is only suitable for rough dosaging purposes with individual doses of e.g. 2 ml.
EP 174 757 A1 describes a dosaging system in which the individual components such as the storage container, refilling point, pump and catheter are interconnected by connecting lines. The components are made from an elastomer. Such dosaging systems are difficult to implant due to the construction from numerous different parts.
EP 335 671 A1 discloses a dosaging system, in which the essential components are combined into a single structural unit. However, compared with the overall volume of the dosaging system, the size of the storage area in which the medication to be administered is located is small. In addition, the pumping mechanism provided has a complicated construction. The operability of the overall system is exclusively based on the elasticity of its components.
EP 342 945 A2, EP 342 946 A2 and EP 342 947 A2 disclose a very similar dosaging system to that described in EP 335 671 A1. Here again the pumping mechanism used is very complicated and the quantity of the medication which can be received in the storage space is small compared with the overall volume of the space taken up. Here again the operability of the dosaging system is based on the deformability of the housing containing the pumping mechanism and the actual pumping mechanism.
The problem of the invention is to avoid the disadvantages known from the prior art. Thus, in particular, a large storage space compared to the overall dimensions of the dosaging system is to be provided, so as to be able to perform a maximum number of individual administrations before the storage space has to be refilled. Simultaneously the construction of the pumping mechanism is to be made as simple as possible and therefore less prone to faults. Finally, by suitable measures, it is to be ensured that small, precisely defined active substance quantities are easily administered and the system can be refilled without great effort a number of times. In particular, a dosaging system according to the invention is to be suitable for an at least partial implantation in bones or bone cavities.
This problem is solved by a dosaging system of the aforementioned type, which has the fo

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patent: 4443218 (1984-04-01), Decant, Jr. et al.
patent: 4936831 (1990-06-01), Jaehrling et al.
patent: 5085644 (1992-02-01), Watson et al.
Lynch, J: Ruckenmarksnahe Opiatanalgesie mit Pumpensystemen in der Tumorschmerztherapie, Medizintechnik, 112. Jg., 1, 1992, pp. 22-27.

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