Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-05-30
2000-01-18
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
435182, 514 12, 6048911, A61F 200, A61K 922, C12N 1104
Patent
active
060155728
ABSTRACT:
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process. An implantable device containing recombinant GDNF secreting cells encapsulated in a semipermeable membrane may be used to treat nerve damage in patients suffering from disorders such as Parkinson's disease.
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Bektesh Susan
Collins Franklin D.
Doherty Daniel H.
Lile Jack
Lin Leu-Fen H.
Amgen Inc.
Curry Daniel R.
Gucker Stephen
Hutzell Paula K.
Levy Ron K.
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