Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1988-10-06
1991-04-30
Green, Randall L.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 4, 604 52, 604 53, 604153, 604246, 6048921, A61M 3100
Patent
active
050114727
ABSTRACT:
Devices and methods are disclosed to provide hybrid, modular systems for the constitutive delivery of appropriate dosages of active factor to a subject and, in some instances, to specific anatomical regions of the subject. The systems include a cell reservoir containing living cells capable of secreting an active agent, which is preferably adapted for implantation within the body of the subject and further includes at least one semipermeable membrane, whereby the transplanted cells can be nourished by nutrients transported across the membrane while at the same time protected from immunological, bacterial, and viral assault. The systems further include a pumping means, which can be implantable or extracorporeal, for drawing a body fluid from the subject into the cell reservoir and for actively transporting the secreted biological factors from the cell reservoir to a selected region of the subject.
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Aebischer Patrick
Galletti Pierre M.
Miracoli Luigi
Panol George
Brown University Research Foundation
Engellener Thomas J.
Green Randall L.
Iantorno Stephanie L.
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