Implantable biological tissue and process for preparation thereo

Details Implantable biological tissue and process for preparation thereo Implantable biological tissue and process for preparation thereo

1984-11-13

1987-03-03

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 1, 623 2, 623 66, 8 9411, A61F 202, A61F 206, A61F 224

Patent

active

046472835

ABSTRACT:
A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification of the implanted tissue.

REFERENCES:
patent: 4378224 (1983-03-01), Nimni et al.
patent: 4481009 (1984-11-01), Nashef
Drescher; Chemical Abstract 71:48030c; "Inhib. Eff. of Metal Salts on Exp. Vas. Calcinosis", 1969.
Thomas et al.; Chemical Abstract 67:98480n; "Mineralization of Human & Bovine Tissue in Vitro"; 1967.
Urist, M. R. and Adams, J. M.; Effects of Various Blocking ReAgents Upon Local Mechanism of Calcification Arch. Path 81,325 (1966).
Sobel, A. E. and Burger, M.; Calcification XIV Proc. Soc. Exp. Biol-. Med. 87,7-3 (1954).

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