Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1994-09-30
1998-01-20
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424488, 424602, A61K 910, A61K 4736
Patent
active
057098751
ABSTRACT:
The invention relates to a material which can be implanted in living tissue, in particular bony tissue, and having a rate of biodegradation adapted to the rate at which the tissue is regenerated; this material may comprise an active substance in order to achieve a therapeutic effect of prolonged duration. This material comprises (a) a calcium phosphate with apatitic or triclinic structure comprising HPO.sub.4 and PO.sub.4 groups, (b) a biodegradable oside or polyoside, in particular dextran, (c) if required, an active substance comprising amine groups such as netilmicin and/or gentamicin in sulphate form. The implantable material according to the invention may be produced without heat by compacting its various constituents in the powdery state.
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A French-English Dictionary For Chemists, A.M. Patterson, John Wiley & Sons, NY, 2nd Ed. 1963, p. 99.
Bonnevialle Paul
Julia Anne
Lebugle Albert
Rodriguez Fernand
Centre National de la Rechierche Scientifique (C.N.R.S)
Dutton, Jr. Harold H.
Webman Edward J.
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