Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1994-01-10
1998-09-01
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, 424424, 424426, 424427, 424430, 424434, 424437, 424489, 424490, 514866, 514814, A61K 950, A61K 914
Patent
active
058008284
ABSTRACT:
Immunoisolatory vehicles having a core and a surrounding jacket are disclosed, the core having a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells capable of secreting a biologically active product or of providing a biological function to a patient, the cells dispersed in a biocompatible matrix formed of a hydrogel or an extracellular matrix component, and the external jacket being permselective, biocompatible and having a molecular weight cutoff permitting passage of molecules between the patient and the core through said jacket to provide said biological product or function.
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Aebischer Patrick
Christenson Lisa
Dionne Keith E.
Emerich Dwaine F.
Gentile Frank T.
Bawa Raj
Brown University Research Foundation
Elrifi Ivor R.
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