Implantable biocompatible immunoisolatory vehicle for delivery o

Details Implantable biocompatible immunoisolatory vehicle for delivery o Implantable biocompatible immunoisolatory vehicle for delivery o

1995-05-24

1998-08-25

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424424, 424426, 424427, 424430, 424434, 424437, 424489, 424490, 514814, 514866, A61K 950, A61K 914

Patent

active

057981132

ABSTRACT:
A method of providing a biologically active molecule or metabolic or immunologic function to a patient, comprising implanting into the body of the patient at least one immunoisolatory vehicle comprising a core comprising a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells dispersed in a biocompatible matrix formed of a hydrogel or extracellular matrix components, said cells being capable of secreting a biologically active product or of providing a metabolic or immunologic function to the patient; and an external jacket surrounding said core, said jacket being formed from a thermoplastic or hydrogel, said jacket being free of said cells projecting externally therefrom, said jacket being biocompatible and having a molecular weight cutoff permitting passage of molecules between the patient and the core through said jacket to provide said biologically active product of function.

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