Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2005-11-01
2005-11-01
Kunz, Gary (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S423000, C424S424000, C424S425000, C424S426000, C424S489000, C424S490000, C424S198100, C604S890100
Reexamination Certificate
active
06960351
ABSTRACT:
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. The vehicle is particularly well-suited to delivery of insulin from immunoisolated islets of Langerhans, and can also be used advantageously for delivery of high molecular weight products, such as products larger than IgG. A method of making a biocompatible, immunoisolatory implantable vehicle, consisting in a first embodiment of a coextrusion process, and in a second embodiment of a stepwise process. A method for isolating cells within a biocompatible, immunoisolatory implantable vehicle, which protects the isolated cells from attack by the immune system of an individual in whom the vehicle is implanted. A method of providing a needed biological product or metabolic function to an individual, comprising implanting into the individual an immunoisolatory vehicle containing isolated cells which produce the product or provide the metabolic function.
REFERENCES:
patent: 3093831 (1963-06-01), Jordan
patent: 3615024 (1971-10-01), Michaels
patent: 4251387 (1981-02-01), Lim et al.
patent: 4298002 (1981-11-01), Ronel
patent: 4324683 (1982-04-01), Lim et al.
patent: 4352883 (1982-10-01), Lim
patent: 4353888 (1982-10-01), Sefton
patent: 4391909 (1983-07-01), Lim
patent: 4407957 (1983-10-01), Lim
patent: 4409331 (1983-10-01), Lim
patent: 4479796 (1984-10-01), Kallok
patent: 4663286 (1987-05-01), Tsang et al.
patent: 4670014 (1987-06-01), Huc
patent: 4686098 (1987-08-01), Kopchick
patent: 4689293 (1987-08-01), Goosen
patent: 4749620 (1988-06-01), Rha
patent: 4789550 (1988-12-01), Hommel
patent: 4806355 (1989-02-01), Goosen
patent: 4868121 (1989-09-01), Scharp
patent: 4883666 (1989-11-01), Sabel
patent: 4892538 (1990-01-01), Aebischer
patent: 4902295 (1990-02-01), Walthall
patent: 4942129 (1990-07-01), Goosen
patent: 4960415 (1990-10-01), Reinmuller
patent: 4997443 (1991-03-01), Walthall et al.
patent: 5002661 (1991-03-01), Chick
patent: 5026365 (1991-06-01), Rossini
patent: 5082670 (1992-01-01), Gage
patent: 5084350 (1992-01-01), Chang
patent: 5106627 (1992-04-01), Aebischer
patent: 5156844 (1992-10-01), Aebischer
patent: 5158881 (1992-10-01), Aebischer et al.
patent: 5283187 (1994-02-01), Aebischer et al.
patent: 5284761 (1994-02-01), Aebischer et al.
patent: 5292515 (1994-03-01), Moro
patent: 5389535 (1995-02-01), Aebischer et al.
patent: 5800828 (1998-09-01), Dionne et al.
patent: 5874099 (1999-02-01), Dionne et al.
patent: 6083523 (2000-07-01), Dionne et al.
patent: 6322804 (2001-11-01), Dionne et al.
patent: 127989 (1984-12-01), None
patent: 147939 (1985-07-01), None
patent: 188309 (1986-07-01), None
patent: 228067 (1987-07-01), None
patent: 2094750 (1982-09-01), None
patent: 2094832 (1982-09-01), None
patent: 2094833 (1982-09-01), None
patent: 2192171 (1988-01-01), None
patent: WO 84/01287 (1984-04-01), None
patent: WO 87/03802 (1987-04-01), None
patent: WO 87/04367 (1987-07-01), None
patent: WO 88/00237 (1988-01-01), None
patent: WO 88/10103 (1988-12-01), None
patent: WO 89/04655 (1989-06-01), None
patent: WO 90/02580 (1990-03-01), None
patent: WO 90/05552 (1990-05-01), None
patent: WO 90/15637 (1990-12-01), None
patent: WO 91/00119 (1991-01-01), None
patent: WO 91/02498 (1991-03-01), None
patent: WO 91/07951 (1991-06-01), None
patent: WO 91/09119 (1991-06-01), None
patent: WO 91/10425 (1991-07-01), None
patent: WO 91/10470 (1991-07-01), None
patent: WO 91/07525 (1992-05-01), None
patent: WO 91/00063 (1993-01-01), None
patent: WO 91/00127 (1993-01-01), None
patent: WO 91/00128 (1993-01-01), None
patent: WO 91/00439 (1993-01-01), None
patent: WO 91/03901 (1993-03-01), None
patent: WO 91/21902 (1993-11-01), None
patent: WO 91/22427 (1993-11-01), None
Aebischer et al. (1986).Trans. Am. Soc. Artif. Intern. Organs XXXII: 134-137.
Aebischer et al. (1991).Biol. Abstr. 91: 762.
Aebischer et al. (1991).Biomaterials 12: 50-56.
Aebischer et al. (1991).Brain Research 560: 43-49.
Aebischer et al. (1991).Exn. Neurol. 111: 269-275.
Aebischer et al. (1991).J. Biomech. Eng. 113: 178-183.
Aebischer and Goddard (1991).Science 252: 133.
Algire et al. (1954).J. National Cancer Institute 15: 493-507.
Altman et al. (1984).Trans. Am. Soc. Artif. Intern. Organs XXX:382-386.
Altman et al. (1986).Diabetes 35: 625-633.
Amicon Corp. Publication No. 442C, pp. 1-4.
Archer et al. (1980).J. Surgical Research 28: 77-85.
Bontempo et al. (1987).Blood, 69: 1721-1724.
Brandrup et al. (1989).Polymer Handbook.
Britt et al. (1981).Diabetes 30: 580-583.
Cabasso (1980).Encyclopedia of Chemical Technology 12: 492-517.
Cai et al. (1988).Artificial Organs 12: 388-393.
Cepko (1988).Neuron 1: 345-353.
Christenson et al. (1989).J. Biomed. Mat. Res. 23: 705-718.
Christenson, Ph.D. (1990). Thesis, Brown University.
Cohen et al. (1990).J. Am. Chem. Soc. 112: 7832-7833.
Cole et al. (1992).Diabetologia 35: 231-237.
Darquy et al. (1985).Diabetologia 28: 776-780.
Darquy et al. (1987).Trans. Am. Soc. Artif. Intern. Organs XXXIII: 356-358.
Dionne (1989). Thesis Ph.D., Massachusetts Institute of Technology: 170-184.
Duquy et al. (1988).J. Biomed. Mat. Res. 22: 1061-1070.
Edmunds et al. (1989).Applied Biochemistry and Biotechnology 20-21: 603-619.
Faithfull (1987).Anaesthesia 42: 234-242.
Fan et al. (1990).Diabetes 39: 519-522.
Fu et al. (1989).Transplantation 47: 432-435.
Gordon et al. (1987).Nature 326: 403-405.
Hama et al. (1983).Pain 52: 223-231.
Hoffman et al. (1990).Exp. Neurol. 110: 39-44.
Hong et al. (1989).Int. J. Radiation Oncology Biol. Phys. 16: 1097-1099.
Iwata et al. (1989).Diabetes 38: 224-225.
Jaeger et al. (1990).Progress in Brain Research 82: 41-46.
Jaeger et al. (1991).Brain Research 551: 163-170.
Jarret et al. (1976).The Lancet 2: 1009-1012.
Jolley et al. (1977).Transplantation Proceedings IX: 363-365.
Klomp et al. (1983).Journal of Biomedical Materials Research 17: 865-871.
Lacy et al. (1979).Science 204: 312-313.
Lacy et al. (1991).Science 254: 1782-1784.
Land et al. (1983).Nature 304: 596-602.
Leung et al. (1983).Artificial Organs 7: 208-212.
Lim et al. (1980).Science 210: 908-910.
Livett (1984).Physiology Reviews 64: 1103-1161.
Maniats et al. (1978).Can. J. Comp. Med. 42: 428-437.
Matthews et al. (1981).Recent Advances in Germfree Research: 61-64.
NASA Tech. Briefs MSC-21480, U.S. Gov't. Printing Office, Washington, D.C.
NASA Tech. Briefs NPO-17517, vol. 15 #1 p. 54, U.S. Gov't. Printing Office, Washington, D.C.
O'Shea et al. (1984).Biochem. Biophys. Acta., 804: 133-136.
O'Shea et al. (1986).Diabetes 35: 943-946.
Reach (1984).Biomed. Biochim. Acta. 43: 569-576.
Ricordi et al. (1988).Transplantation 45: 1148-1151.
Ronel et al. (1983).Journal of Biomedical Materials Research 17: 855-864.
Sagen et al. (1986).Proc. Natl. Acad. Sci. USA 83: 7522-7562.
Sagen et al. (1990).Pain 42: 69-79.
Sagen et al. (1993).J. Neuroscience 13: 2415-2423.
Sanberg et al. (1979).Exp. Neurol. 66: 444-4466.
Scharp et al. (1984).World J. Surg. 8: 221-229.
Sefton et al. (1987).Biotech. and Bioeng. XXIX: 1135-1143.
Short et al. (1990).Dev. Neurosci. 12: 34-45.
Soeidner et al. (1965).Diabetes 14: 771-779.
Sugamori et al. (1989).Trans. Am. Soc. Artif. Intern. Organs XXXV: 791-799.
Sun et al. (1977).Diabetes 26:1136-1139.
Sun et al. (1984).Applied Biochem. Biotechnol. 10: 87-99.
Sun et al. (1986).Trans. Am. Soc. Artif. Intern. Organs XXXII: 39-41.
Sun et al. (1987).Biomat. Art. Celis. Art. Org. 15: 483-496.
Sun et al. (1987).CRC Critical Reviews in Therapeutic Drug Carrier Systems 4: 1-12 (1987).
Sun (1987).Trans. Am. Soc. Artif. Intern. Organs XXXIII: 787-790.
Sun (1988).Methods in Enzymology 137: 575-580.
Tresco et al. (1992).ASAIO Journal 38: 17-23.
Tze et al. (1976).Nature 264: 466-467.
Tze et al. (1979).Diabetologia247-252.
Tze et al. (1982).Transplantation 33: 563-564.
Weber et al. (
Aebischer Patrick
Christenson Lisa
Dionne Keith E.
Emerich Dwaine F.
Gentile Frank T.
Brown University Research Foundation
Elrifi, Esq. Ivor R.
Gollamudi S.
Kunz Gary
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
LandOfFree
Implantable biocompatible immunoisolatory vehicle for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Implantable biocompatible immunoisolatory vehicle for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Implantable biocompatible immunoisolatory vehicle for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3471239