Implant preparations containing bioactive macromolecule for sust

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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424426, 424468, 424484, 514 3, 514 21, 514964, A61K 922, A61K 3827, A61K 3828, A61K 4744

Patent

active

059393807

ABSTRACT:
Implant preparations capable of sustained action when inserted are comprised of powder of a natural lipoidal substance in thorough admixture with bioactive macromolecule, followed by compression under pressure into a disc or rod that can be broken and used in small pieces as well.

REFERENCES:
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patent: 4579730 (1986-04-01), Kidron et al.
patent: 4775659 (1988-10-01), Thakkar et al.
patent: 4837381 (1989-06-01), Steber et al.
patent: 4882167 (1989-11-01), Jang et al.
Absorption Rate of Hormone-Cholesterol Pellets, by Shimkin et al., Edocrinology, 29, (1941), 1020-1025.
Sustained Release Hormonal Preparations, by Kinel et al., Acta Endocrinologica, 64, (1970), 253-264.
The Effect of Dose and Nutritive State of the Renotrophic and Androgenic Activities of Various Steroids, by Kochakian, Am. J. Physiol. 145 (1945), 549-556.
Sustained-Release Hormonal Preparations XV: Release of Progesterone Pellets In Vivo, by Joseph et al., J. Pharm. Sci, 66 (1977), 490-493.

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