Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-31
1998-09-01
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424424, 514 12, 514 21, A61K 924, A61K 3818, A61K 3827
Patent
active
058011412
ABSTRACT:
The invention relates to implants for the parenteral administration of an essentially uniform and continuous amount of a biologically active protein, peptide or polypeptide over an extended period of time which comprises a compacted, indented and partially coated composition containing from one to three layers of a homogeneous core mixture comprising about 20% to about 80% of a biologically active protein, a peptide or a polypeptide; about 10% to about 75% of a fat, a wax or a mixture thereof; 0% to about 25% of a buffer, a salt, a sugar or a mixture thereof; 0% to about 15% of a filler, on a weight basis of the total weight of the core mixture. The partial coating of a semipermeable material comprises about 5% to about 50%, on a weight basis of the total weight of the implant. The invention also relates to methods for increasing and maintaining elevated blood levels of biologically active proteins, peptides and polypeptides in animals by the administration of said implants.
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Cady Susan Mancini
Haughey Theresa Rice
Johnson David Farley
Steber William David
American Cyanamid Company
Climenson Peggy A.
Russel Jeffrey E.
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