Impedance spectroscopy system for ischemia monitoring and detect

Surgery – Diagnostic testing – Measuring electrical impedance or conductance of body portion

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A61B 504

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active

058072721

ABSTRACT:
An impedance spectroscopy tissue status monitoring and measurement system is disclosed. The system uses a synthesizer to generates electrical signals of selected frequencies. An electrical current source is responsive to the synthesizer and generates electrical currents for transmission through tissue. Electrodes or inductive coils of the system apply the electrical current to the tissue and sense voltages generated in the tissue in response to the electrical current. A controller determines the spectral response of the tissue by detecting magnitude and phase information of the electrical energy transmitted through the tissue. The information is then used to determine volumes of compartments within the tissue and ionic concentrations of compartmental fluids. Capacitive effects derived from the phase information are used to determine cell membrane functionality within the tissue. From this analysis, status, specifically, ischemia, may be determined on an absolute basis.

REFERENCES:
patent: 5280429 (1994-01-01), Withers
patent: 5282480 (1994-02-01), Hudrlik
Gebhard, M.M., "Impedance Spectroscopy: A Method for Surveillance of Ischemia Tolerance of the Heart," Thorac Cardiovasc. Surgeon 35, pp. 26-32 (1987).

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