Immunotoxins, process for their preparation and pharmaceutical c

Details Immunotoxins, process for their preparation and pharmaceutical c Immunotoxins, process for their preparation and pharmaceutical c

1987-07-14

1991-01-01

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530390, 530389, 530402, 530403, 530404, 530405, 530406, 530370, 424 8591, 514885, C07K 1500, C07K 1528, C07K 306

Patent

active

049819534

ABSTRACT:
The present invention relates to the immunotoxines which are obtained by the covalent coupling of, on the one hand, trichosanthin or trichokirin, as such or appropriately modified with, on the other hand, an antibody or antibody fragment, used in its natural form or correctly modified, which is capable of selectively recognizing an antigen carried by the target cells to be destroyed.

REFERENCES:
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CA, vol. 96, No. 11, 3-15-82, p. 40, No. 97573c.
CA, vol. 95, No. 4, 7-24-81, p. 328, No. 30276y.

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