Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-04-18
1997-04-15
Adams, Donald E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303873, 530370, 5303917, 530326, 536 2353, C07K 1628, C07K 1646, C12P 1934
Patent
active
056210833
ABSTRACT:
The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.
REFERENCES:
patent: 4675382 (1987-06-01), Murphy
patent: 4769326 (1988-09-01), Rutter
patent: 4894443 (1990-01-01), Greenfield et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5013653 (1991-05-01), Huston et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5169939 (1992-12-01), Gefter et al.
patent: 5376546 (1994-12-01), Bernhard et al.
patent: 5416202 (1995-05-01), Bernhard et al.
Riechmann et al. [Nature 332:323-327 (1988)].
Better et al., Protein ant-CD5 ricin immunoconjugates from bacterially produced Fab' and F(ab')2', Proc. Natl. Acad. Sci. USA 90:457-461, Jan. 1993.
Strockbine et al., J. Bact. 170:1116-1122 (Mar. 1988).
Tolan et al., J. Biol. Chem. 259(2):1127-1131 (1984).
Bacha, et al, J. Exp. Med., 167:612-622 (1988).
Batra, et al., J. Biol. Chem., 265(25):15198-15202 (1990).
Chaudrary, et al., Nature, 339:394-397 (1989).
Colombatti, et al., J. Immunol., 131(6):3091-3095 (1983).
Descotes, et al., J. Immunopharmac., 7(4):455-463 (1985).
Kohr, et al., Abstr. T15, The Protein Society, 4th Symposium. Aug. 11-15, 1990, San Diego, California.
Montecucchi, et al., Int. J. Peptide Protein Res., 33:263-267 (1989).
O'Hare, et al., FEBS, 273:200-204 (1990).
Sivam, et al., Cancer Research, 47:3169-3173 (1987).
Stirpe, et al., J. Biol. Chem., 255(4):6947-6953 (1980).
Westby, et al., Bioconjugate Chem., 3:375-381 (1992).
Williams, et al., Protein Engineering, 1(6):493-498 (1987).
Barta, et al., Mol. and Cell Biology, 11:2200-2205 (1991).
Queen, et al., Proc. Nat'l. Acad., Sci. (USA), 86:10029-10033 (1989).
The Washington Post. A4, Aug. 21, 1992.
Better Marc D.
Carroll Stephen F.
Studnicka Gary M.
Adams Donald E.
Xoma Corporation
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