Immunotoxin with in vivo T cell suppressant activity and methods

Details Immunotoxin with in vivo T cell suppressant activity and methods Immunotoxin with in vivo T cell suppressant activity and methods

1994-09-19

1998-03-10

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated to proteinaceous toxin or fragment thereof

4241781, 4242361, 4242381, 53038822, 5303887, 53038875, 5303917, A61K 39395, C07K 1628

Patent

active

057258570

ABSTRACT:
In one embodiment, the invention provides a method of treating an autoimmune disease in an animal comprising administering to the animal an antibody-CRM9 conjugate which routes by the anti-CD3 pathway, or derivatives thereof, under conditions such that the autoimmune disease is treated. In another embodiment, the invention provides an anti-V.beta.-CRM9 immunoconjugate. In a further embodiment, the invention provides a method of treating T cell leukemias or lymphomas in an animal comprising administering to the animal an antibody-CRM9 conjugate which routes by the anti-CD3 pathway, or derivatives thereof, under conditions such that the T cell leukemias or lymphomas are treated.

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