Immunotoxin with in-vivo T cell suppressant activity

Details Immunotoxin with in-vivo T cell suppressant activity Immunotoxin with in-vivo T cell suppressant activity

1991-02-11

1992-12-01

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

5303917, 5303919, A61K 3944, C07K 1528

Patent

active

051679566

ABSTRACT:
The present invention relates to an immunotoxin. The invention further relates to a method of treating T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases by administering an immunotoxin.

REFERENCES:
Pastan et al (1991) Science 254:1173-1177.
Hauser (1991) Science 254:1167-1172.
Greenfield et al (1987) Science 238:536-539.
Johnson et al (1988) J. Biol. Chem. 263(3):1295-1300.
Myers et al (1989) J. Immunol. Methods 121:129-142.
Neville, Jr. et al. (1989) J. Biol. Chem. 264(25):14653-61.
Urban et al (1988) Cell 54:577-592.

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